Neurology

Echo-Volumar Imaging

Echo volumar imaging (EVI) has the potential to become an alternative to echo planar imaging (EPI) as the accelerating development of parallel imaging and large-scale array coils transforms clinical imaging [Rabrait et al 2008, van der Zwaag et al 2006, Witzel et al 2008]. The high temporal resolution reduces intrascan motion effects, it enables assessment of regional differences in hemodynamic response function and it reduces aliasing of physiological noise. However, geometrical distortion and blurring due to field inhomogeneity and relaxation are significant challenges. Practical applications are hampered by time-consuming image reconstruction and real-time fMRI with EVI has yet to be demonstrated.

In this study we develop multiple-slab EVI for high field applications to reduce geometrical distortion and blurring. We demonstrate real-time fMRI using custom designed high-performance data transfer and analysis tools. We compare BOLD sensitivity with conventional EPI, characterize the time course of the hemodynamic response function in single trial paradigms and investigate resting state networks.

Citations

Posse, S., Ackley, E., Mutihac, R., Rick, J., Shane, M., Murray-Krezan, C., Zaitsev, M., Speck, O., "Enhancement of temporal resolution and BOLD sensitivity in real-time fMRI using multi-slab echo-volumar imaging.," Neuroimage, 2012 Feb 28. doi:10.1016/j.neuroimage.2012.02.059.

Posse, S., Ackley, E., Mutihac, R., Zhang, T., Hummatov, R., Akhtari, M., Chohan M.O., Fisch, B., Yonas, H., "High-Speed Real-Time Resting State fMRI using Multi-Slab Echo-Volumar Imaging," Frontiers in Human Neuroscience,(7), 2013 Aug 26; doi:10.3389/fnhum.2013.00479.