Surojit Paul, PhD
Associate Professor of Neurology and Neurosciences
CV and profile (VIVO)
The Surojit Paul Laboratory is interested in understanding the cellular and molecular basis of neuronal injury and the development of strategies for intervention in neurological disorders related to excitotoxicity and oxidative stress.
The Paul lab is currently investigating the role of the brain-enriched tyrosine phosphatase, STEP in the regulation of neuronal excitotoxicity. STEP is predominantly expressed in the neurons of the cortex, striatum and hippocampus and is activated following neuronal injury to confer neuroprotection. Inactivation or loss of this intrinsic survival pathway is associated with exacerbation of brain injury in neurological disorders associated with excitotoxicity. Based on these findings, the lab's researchers developed a novel STEP-derived peptide, and using animal models of cerebral stroke, show that restoration of the STEP signaling pathway with intravenous administration of this peptide provide significant neuroprotection against ischemic brain damage, even when administered several hours after the onset of the insult.
The primary focus of The Paul lab's current NIH-funded projects is to evaluate whether restoration of STEP signaling could provide long-term neuroprotection and facilitate post-ischemic recovery, as well as understanding the detrimental cascades regulated by STEP. Additional interests of the laboratory are to evaluate the role of STEP in regulating the key pathways affected by oxidative stress during aging and age-associated disorders. Experimental approaches encompass a broad range of interdisciplinary methods, including neuronal cultures, rodent models of cerebral ischemia and traumatic brain injury, mouse genetic models, magnetic resonance imaging, biochemical and molecular studies, immunohistochemistry and behavioral evaluation.