Presurgical Mapping in Patients with Brain Tumors, Epilepsy and Arterioveneous Malformations using Task Based and Resting State Real-Time fMRI

Localization of eloquent cortex adjacent to brain lesions is of critical value in presurgical planning and decision-making. Mapping of resting-state networks (RSNs) using fMRI has been suggested as an alternative to task-based fMRI, however, the utility for presurgical planning is still under investigation. In this study, we characterize the sensitivity of novel high-speed resting-state fMRI for mapping eloquent cortex and disease-related changes in connectivity in patients with brain lesions.

The goal of this research is to develop a multi-modal imaging approach for presurgical mapping to guide neurosurgical resection and to minimize post-operative neurological deficits. Methods include task based and resting state ultra-high-speed real-time fMRI, 3D high-speed MR spectroscopic imaging, diffusion tensor MRI and concurrent fMRI-EEG, in correlation with a standard clinical workup that includes high-resolution MRI, MEG and PET.